Sex Differences in Cardiovascular Pharmacology

Cardiovascular disease (CVD) is the leading global cause of mortality, impacting individuals of all genders. Despite significant progress in understanding disease patterns in both women and men, a concerning trend of undertreatment persists due to gender-specific responses to cardiovascular drugs, resulting in diminished benefits from available therapeutic strategies. While current guidelines do not recommend differential treatment of CVD based on gender, an emerging body of research indicates sex dimorphism in the pathophysiology of CVD, resulting in varied pharmacological responses to cardiovascular agents. The pharmacodynamic mechanisms underlying gender differences are not fully elucidated, emphasizing the need for more studies focusing on women to optimize sex/gender-specific therapy and improve clinical outcomes in female CVD patients. Consequently, the present special issue aims to explore sex differences in therapeutic responses to cardiovascular drugs, a crucial step toward enhancing clinical outcomes and providing a more personalized treatment approach. This initiative aims to generate new ideas and identify potential pharmacological targets for novel drug discovery in the cardiovascular field.

The limited comprehension of pharmacological mechanisms in gender differences related to cardiovascular diseases underscores the need for more focused studies on women, aiming to optimize sex-specific therapy and enhance clinical outcomes for female CVD patients. The goal of this special issue is to focus on the investigation of sex differences in therapeutic responses to cardiovascular drugs, with the ultimate objective of improving clinical outcomes and refining personalized treatment approaches.

Specific Pharmacological Responses: Explore and elucidate the mechanisms underlying sex-specific responses to cardiovascular drugs.

Gender Dimorphism in Cardiovascular Pharmacology: Investigate and analyze sex dimorphism in the pathophysiology of cardiovascular diseases, highlighting its implications for drug responses.

Clinical Outcomes and Treatment Approaches: Examine the impact of sex differences on clinical outcomes in patients with cardiovascular diseases and animal models. Propose personalized treatment approaches based on gender-specific responses, aiming to enhance therapeutic efficacy and address the distinct needs of both male and female individuals affected by cardiovascular conditions.

Optimizing Sex-Specific Therapy: Focus on studies aiming to optimize therapy tailored to the sex of the individual, considering pharmacodynamic and pharmacokinetic factors.

Pharmacological Targets for Novel Drug Discovery: Identify and discuss potential pharmacological targets for novel drug discovery in the cardiovascular field, emphasizing sex-specific considerations.

Manuscript Types:

- Original Research Articles: Presenting novel findings and insights.

- Review Articles: Synthesizing existing knowledge and highlighting gaps.

- Clinical Studies: Investigating sex-specific responses in real-world scenarios.

- Pharmacological Mechanism Studies: Exploring the molecular basis of sex differences in drug responses.

- Perspective and Opinion Pieces: Offering unique viewpoints on the subject.

Contributors are encouraged to submit manuscripts that advance our understanding of sex differences in cardiovascular pharmacology, ultimately contributing to more effective and personalized treatment strategies.

More info : cardiology.pencis.com

Contact : cardiology@pencis.com

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