Wednesday, 3 September 2025

Shingles Vaccine May Reduce Heart Attack and Stroke Risk: New Research Insights

Recent research is shedding light on a surprising benefit of the shingles vaccine: protection against cardiovascular events like heart attacks and strokes. While the primary purpose of the vaccine is to prevent shingles (herpes zoster), emerging evidence suggests it may also help reduce the risk of heart and vascular complications, potentially providing long-term health benefits.



Shingles Vaccination and Reduced Cardiovascular Risk

Several studies, including a comprehensive global meta-analysis and a large-scale South Korean observational study, have found an association between shingles vaccination and a reduced risk of cardiovascular events. Adults who received the shingles vaccine were less likely to experience heart attacks or strokes compared to those who were not vaccinated.

The protective effect appears to last for several years, with one South Korean study reporting benefits extending up to eight years. The most significant reduction in cardiovascular risk was observed during the first few years after vaccination.

How Could the Shingles Vaccine Protect Your Heart?

The mechanism behind this unexpected benefit may be linked to how shingles affects the body. Herpes zoster infection can trigger inflammation in blood vessels, damage arterial walls, and increase blood clot formation. By preventing shingles, the vaccine may indirectly reduce these cardiovascular risks.

Who Benefits Most?

Studies suggest certain groups may see greater cardiovascular benefits from the shingles vaccine:

  • Men appear to gain more protection than women.

  • Individuals under 60 show more significant risk reduction.

  • People with unhealthy lifestyles may also experience pronounced benefits.

Vaccine Options

Both types of shingles vaccines

  • the older live zoster vaccine

  • the newer recombinant vaccine (Shingrix) have been linked to a reduction in cardiovascular events. This indicates that the protective effect is not limited to one specific vaccine type.

Implications for Public Health

If confirmed by further research, these findings could have broad public health implications:

  • Dual Benefits: The shingles vaccine may offer protection not only against shingles but also against cardiovascular events.

  • Reducing Health Disparities: Incorporating shingles vaccination into public health programs could reduce cardiovascular disease burden and narrow disparities among different population groups.

Limitations and the Need for Further Research

It’s important to note that most evidence comes from observational studies. While these studies can show associations, they cannot prove a cause-and-effect relationship. Further research is needed to:

  • Confirm the cardiovascular benefits of shingles vaccination.

  • Understand the underlying mechanisms.

  • Explore whether these benefits are consistent across diverse populations beyond the studied cohorts.

Conclusion

The shingles vaccine may offer more than just protection against painful shingles. Emerging research suggests it could also play a strategic role in safeguarding heart health, especially in certain high-risk groups. While we await more definitive evidence, these findings highlight an exciting potential additional benefit of getting vaccinated against shingles.


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International Conference on Cardiology and Cardiovascular Medicine




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